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TP7 Mechanisms underlying hippocampal interneuron plasticity and their role in population activity in vivo

Prof. Dr. Jozsef Csicsvari

The hippocampus incorporates complex neuronal circuits, which play important roles in the encoding and recall of spatial memories. Hippocampal principal cells encode space by firing in a location-dependent manner, and together these place cells form a cognitive map of allocentric space. New maps formed as a result of spatial learning are accompanied by plastic changes of both pyramidal cell-pyramidal cell and pyramidal cell-interneuron connections. Here, combined in vivo electrophysiology and optogenetic approaches will be used to test the role of interneuron type specific plasticity on the formation and expression of hippocampal place maps. Moreover, we will examine the molecular mechanism behind this type of plasticity and test how these plastic changes might promote map stabilisation. We will also probe the behavioural conditions that are associated with the reorganisation of interneuron circuits in the hippocampus.



Prof. Dr. Marlene Bartos

Physiologisches Institut I

Universität Freiburg

Hermann-Herder-Str. 7

79104 Freiburg



Prof. Dr. Imre Vida

NeuroCure Cluster of Excellence

Institut für Integrative Neuroanatomie

Charité- Universitätsmedizin Berlin

Philippstraße 12

10115 Berlin


Prof. Dr. Peer Wulff

Physiologisches Institut

Universität Kiel

Hermann-Rodewald-Straße 5

24118 Kiel


Dagmar Sonntag

Physiologisches Institut I

Universität Freiburg

Hermann-Herder-Str. 7

79104 Freiburg

Tel: +49(761) 203-67310

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